SDRIFE (baboon syndrome) induced by penicillin

We report a patient who developed a drug rash after systemic administration of amoxicillin. After oral re-exposure to the alternative beta-lactam antibiotic phenoxymethylpenicillin, the patient developed a sharply demarcated V-shaped erythema of the inguinal region, the thighs, and the gluteal area, resembling the buttocks of baboons. Historically, the condition coined 'baboon syndrome' was described as a special entity of a mild systemic cutaneous erythema after oral exposure to type IV allergens, such as nickel, mercury or drugs. Recently, it has been proposed to replace this term by the acronym SDRIFE (symmetrical drug-related intertriginous and flexural exanthema) for those reactions occurring after exposure to systemic drugs.