Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor, and heat...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Systematized linear epidermolytic hyperkeratosis.

Dermatology online journal·2014
Same author

Maternal mortality in India: causes and healthcare service use based on a nationally representative survey.

PloS one·2014
Same author

Genetic diversity in Capsicum germplasm based on microsatellite and random amplified microsatellite polymorphism markers.

Physiology and molecular biology of plants : an international journal of functional plant biology·2014
Same author

Field cancerization: concept and clinical implications in head and neck squamous cell carcinoma.

Journal of experimental therapeutics & oncology·2014
Same author

Potent malaria transmission-blocking antibody responses elicited by Plasmodium falciparum Pfs25 expressed in Escherichia coli after successful protein refolding.

Infection and immunity·2014
Same author

Genetic divergence in wild population of endangered yellowtail catfish Pangasius pangasius (Hamilton-Buchanan, 1822) revealed by mtDNA.

Mitochondrial DNA·2014

Related Experiment Video

Updated: Jul 2, 2026

Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Generalized pigmentation due to Addison disease.

Rajesh Kumar1, Sita Kumari, Pradeep Kumar Ranabijuli

  • 1Jagjivan Ram Hospital, Mumbai Central, Mumbai, India. rkderm@gmail.com

Dermatology Online Journal
|August 14, 2008
PubMed
Summary
This summary is machine-generated.

A 10-year-old boy was diagnosed with Addison disease, a rare adrenal insufficiency, due to symptoms like hyperpigmentation and abdominal pain. This condition involves decreased cortisol and adrenal atrophy, requiring prompt medical attention.

Related Experiment Videos

Last Updated: Jul 2, 2026

Quantification of Hypopigmentation Activity In Vitro
06:08

Quantification of Hypopigmentation Activity In Vitro

Published on: March 6, 2019

Area of Science:

  • Pediatric Endocrinology
  • Internal Medicine
  • Endocrinology

Background:

  • Addison disease is a rare endocrine disorder characterized by adrenal insufficiency.
  • It requires early diagnosis and management to prevent life-threatening complications.

Observation:

  • A 10-year-old boy presented with generalized hyperpigmentation, abdominal pain, behavioral changes, and failure to gain weight.
  • Clinical examination revealed hypotension and hyperpigmentation, particularly on mucosal and frictional surfaces.

Findings:

  • Laboratory tests showed markedly decreased serum cortisol levels.
  • Abdominal CT scan indicated adrenal atrophy, consistent with primary adrenal insufficiency.

Implications:

  • The case highlights the importance of recognizing subtle clinical signs of Addison disease in children.
  • Prompt diagnosis and management are crucial for improving patient outcomes and preventing adrenal crisis.