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Proteoglycan alterations during developing experimental osteoarthritis in a novel hip joint model

S Inerot1, D Heinegård, S E Olsson

  • 1Department of Physiological Chemistry, University of Lund, Sweden.

Summary

Induced hip and knee joint degeneration in dogs revealed significant proteoglycan loss and fragmentation in hip cartilage. Knee cartilage showed decreased proteoglycans but different structural changes, suggesting varied disease mechanisms.

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