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Updated: Jul 2, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Malignant lymphoma without lymphadenopathy.

Usha Kini¹, Betty Alexander, Marjorie Correa

¹Department of Pathology, St. John's Medical College and Hospital, Bangalore 560 034.

The Journal of the Association of Physicians of India

|August 15, 2008

Summary

This summary is machine-generated.

This case report details a rare Hepatosplenic T-Cell Lymphoma (HSTCL) in a multiple myeloma patient. Diagnosis was confirmed via splenectomy and liver biopsy, highlighting HSTCL

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Last Updated: Jul 2, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Area of Science:

Hematology
Oncology
Pathology

Background:

Hepatosplenic T-Cell Lymphoma (HSTCL) is a rare, aggressive non-Hodgkin's lymphoma.
It primarily affects the liver and spleen, often presenting with B symptoms and lacking lymphadenopathy.
HSTCL can be challenging to diagnose due to its rarity and extra-nodal presentation.

Observation:

A 65-year-old man with a history of multiple myeloma developed pancytopenia and massive hepatosplenomegaly.
Clinical suspicion of secondary myelofibrosis arose during follow-up.
The patient underwent therapeutic splenectomy and liver biopsy for investigation.

Findings:

Histopathological and immunohistochemical analysis confirmed the diagnosis of Hepatosplenic T-Cell Lymphoma (HSTCL).
The findings underscore the importance of considering HSTCL in patients with unexplained hepatosplenomegaly and cytopenias, especially those with prior hematologic malignancies.
This case highlights the diagnostic utility of surgical specimens in confirming rare lymphoid neoplasms.

Implications:

Accurate and timely diagnosis of HSTCL is crucial for appropriate treatment and management.
This case contributes to the understanding of HSTCL presentation and diagnosis in complex patient populations.
Further research into the pathogenesis and optimal therapeutic strategies for HSTCL is warranted.