Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Structure01:19

RNA Structure

The basic structure of RNA consists of a string of ribonucleotides attached by phosphodiester bonds. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA) involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three...
RNA Structure01:23

RNA Structure

Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
RNA-seq03:21

RNA-seq

RNA sequencing, or RNA-Seq, is a high-throughput sequencing technology used to study the transcriptome of a cell. Transcriptomics helps to interpret the functional elements of a genome and identify the molecular constituents of an organism. Additionally, it also helps in understanding the development of an organism and the occurrence of diseases. 
Before the discovery of RNA-seq, microarray-based methods and Sanger sequencing were used for transcriptome analysis. However, while microarray-based...
Nucleic Acid Structure01:25

Nucleic Acid Structure

The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA has a double-helix structure. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CellUntangler: Separating distinct biological signals in single-cell data with deep generative models.

Cell genomics·2025
Same author

<i>Struc2mapGAN</i>: improving synthetic cryogenic electron microscopy density maps with generative adversarial networks.

Bioinformatics advances·2025
Same author

A comprehensive survey and benchmark of deep learning-based methods for atomic model building from cryo-electron microscopy density maps.

Briefings in bioinformatics·2025
Same author

MO-SMAC: Multiobjective Sequential Model-Based Algorithm Configuration.

Evolutionary computation·2025
Same author

Single-cell decoding of drug induced transcriptomic reprogramming in triple negative breast cancers.

Genome biology·2024
Same author

Isometric Hamming embeddings of weighted graphs.

Discrete applied mathematics (Amsterdam, Netherlands : 1988)·2023

Related Experiment Video

Updated: Jul 2, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

RNA STRAND: the RNA secondary structure and statistical analysis database.

Mirela Andronescu1, Vera Bereg, Holger H Hoos

  • 1Department of Computer Science, University of British Columbia, 2366 Main Mall, Vancouver, BC, Canada. andrones@cs.ubc.ca

BMC Bioinformatics
|August 15, 2008
PubMed
Summary

RNA STRAND is a new database for RNA secondary structures, offering search, analysis, and download capabilities. This resource aids in improving RNA energy models and evaluating structure prediction programs.

More Related Videos

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

An Assay for Quantifying Protein-RNA Binding in Bacteria
07:02

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

Related Experiment Videos

Last Updated: Jul 2, 2026

RNA Secondary Structure Prediction Using High-throughput SHAPE
13:42

RNA Secondary Structure Prediction Using High-throughput SHAPE

Published on: May 31, 2013

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells
10:34

Probing RNA Structure with Dimethyl Sulfate Mutational Profiling with Sequencing In Vitro and in Cells

Published on: December 9, 2022

An Assay for Quantifying Protein-RNA Binding in Bacteria
07:02

An Assay for Quantifying Protein-RNA Binding in Bacteria

Published on: June 12, 2019

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Molecular Biology

Background:

  • Accessing and analyzing RNA secondary structures is crucial for RNA folding research and model development.
  • Existing databases lack comprehensive capabilities for searching and analyzing known RNA secondary structures.

Purpose of the Study:

  • To introduce RNA STRAND, a curated database of known RNA secondary structures.
  • To provide tools for searching, analyzing, and downloading RNA secondary structure data.
  • To facilitate research in RNA structure, energy modeling, and prediction.

Main Methods:

  • Developed RNA STRAND, a curated database of RNA secondary structures from public sources.
  • Integrated the RNA Secondary Structure Analyser tool for comprehensive statistical analysis.
  • Established protocols for adding new experimental RNA secondary structure data.

Main Results:

  • RNA STRAND offers a searchable and downloadable collection of RNA secondary structures in a common format.
  • The database provides statistical insights into RNA structural motifs and their probabilities.
  • Facilitates improvement of RNA energy models and evaluation of secondary structure prediction tools.

Conclusions:

  • RNA STRAND is a valuable, publicly available resource for RNA secondary structure research.
  • The database provides essential tools for data retrieval, analysis, and contribution.
  • Encourages community contribution to expand the database of known RNA secondary structures.