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Updated: Jul 2, 2026
10:10
Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
Orphans against autoimmunity.
Hozefa Bandukwala1, Mark S Sundrud, Anjana Rao
1Department of Pathology, Harvard Medical School and Immune Disease Institute, 200 Longwood Avenue, Boston, MA 02115, USA.
Immunity
|August 15, 2008
Summary
Researchers identified NR2F6 as a key regulator of T helper 17 cells. Mice lacking NR2F6 developed autoimmune diseases later in life, highlighting its role in immune regulation.
Area of Science:
- Immunology
- Molecular Biology
- Endocrinology
Background:
- T helper 17 (Th17) cells are crucial for host defense but implicated in autoimmune diseases.
- Nuclear receptors are key regulators of gene expression and cellular function.
Purpose of the Study:
- To investigate the role of the nuclear orphan receptor NR2F6 in T helper cell differentiation.
- To determine the in vivo function of NR2F6 in the development of autoimmune disease.
Main Methods:
- Flow cytometry to analyze T helper cell subsets.
- Gene expression analysis to assess NR2F6 targets.
- Phenotyping of NR2F6-deficient mice for autoimmune manifestations.
Main Results:
- NR2F6 acts as a negative regulator of T helper 17 cell differentiation.
- NR2F6-deficient mice exhibit a predisposition to developing late-onset autoimmune disease.
- Identification of NR2F6 as a critical factor in maintaining immune homeostasis.
Conclusions:
- NR2F6 is a significant modulator of Th17 cell responses.
- Loss of NR2F6 function can lead to spontaneous autoimmune conditions.
- NR2F6 represents a potential therapeutic target for autoimmune disorders.
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