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Updated: Jul 2, 2026

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Published on: May 26, 2023
Tumors sound the alarmin(s)
Seth B Coffelt1, Aline B Scandurro
1Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, USA.
Alarmins, crucial immune response molecules, are increasingly recognized for their roles in tumor development and progression. Targeting these alarmins presents a promising new strategy for cancer therapy.
Area of Science:
- Oncology
- Immunology
- Molecular Biology
Background:
- Inflammatory molecules are implicated in tumor development and progression.
- Alarmins, key components of host immune responses, have been underappreciated in cancer biology.
- Specific alarmins like defensins, LL-37, and HMGB1 have known immune functions.
Purpose of the Study:
- To review the role of alarmins in tumor biology.
- To highlight the potential of alarmins as therapeutic targets in cancer.
Main Methods:
- Literature review of studies on alarmins in cancer.
- Analysis of the functions of defensins, LL-37, and HMGB1 in tumor development, progression, and suppression.
Main Results:
- Alarmins are involved in various aspects of tumor biology, including development, progression, and suppression.
- Evidence suggests distinct roles for different alarmins in the tumor microenvironment.
Conclusions:
- Alarmins represent a significant, yet overlooked, area in cancer research.
- Targeting alarmins offers a novel therapeutic avenue for diverse tumor types.
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