Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cholecystitis01:20

Cholecystitis

Cholecystitis is inflammation of the gallbladder, most commonly caused by obstruction of the cystic duct. This blockage prevents bile from draining, leading to gallbladder distension, inflammation, and potentially serious complications. This condition may present acutely or chronically and can happen with or without gallstones.EtiologyAbout 95% of cholecystitis cases are calculous, caused by gallstones blocking the cystic duct, leading to bile accumulation and inflammation of the gallbladder...
Chronic Pancreatitis II: Pathophysiology01:21

Chronic Pancreatitis II: Pathophysiology

Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Chronic Pancreatitis I: Introduction01:25

Chronic Pancreatitis I: Introduction

Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Seladelpar in patients with primary biliary cholangitis and compensated cirrhosis: Efficacy and safety from RESPONSE and ASSURE studies.

Hepatology communications·2026
Same author

Long-Term Use of Fenofibrate as Second-Line Therapy in Primary Biliary Cholangitis: A Retrospective Study.

Alimentary pharmacology & therapeutics·2026
Same author

Betaine in the treatment of steatotic liver disease-Historical fad or a timeless treasure worth reviving?

Hepatology (Baltimore, Md.)·2025
Same author

Advancing diagnosis and management of liver disease in adults through exome sequencing.

EBioMedicine·2023
Same author

Serum miRNA profiles are altered in patients with primary sclerosing cholangitis receiving high-dose ursodeoxycholic acid.

JHEP reports : innovation in hepatology·2023
Same author

Optimizing therapy in primary biliary cholangitis: Alkaline phosphatase at six months identifies one-year non-responders and predicts survival.

Liver international : official journal of the International Association for the Study of the Liver·2023
Same journal

Evaluation of funding gastroenterology research in Canada illustrates the beneficial role of partnerships.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2013
Same journal

Use of fecal occult blood test in hospitalized patients: survey of physicians practicing in a large central Canadian health region and Canadian gastroenterologists.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2013
Same journal

Treatment of chronic hepatitis C in a Canadian Aboriginal population: results from the PRAIRIE study.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2013
Same journal

A randomized controlled trial comparing sequential with triple therapy for Helicobacter pylori in an Aboriginal community in the Canadian North.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2013
Same journal

Improving the quality of colonoscopy bowel preparation using an educational video.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2013
Same journal

Putting an end to the misuse of the fecal occult blood test in diagnostic medicine.

Canadian journal of gastroenterology = Journal canadien de gastroenterologie·2013
See all related articles

Related Experiment Video

Updated: Jul 2, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Primary sclerosing cholangitis.

Marina G Silveira1, Keith D Lindor

  • 1Miles and Shirley Center for Digestive Dieseases, Mayo Clinic and Foundation for Medical Education and Research, Rochester, MN 55905, USA.

Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie
|August 15, 2008
PubMed
Summary
This summary is machine-generated.

Primary sclerosing cholangitis (PSC) is a chronic liver disease causing bile duct inflammation and fibrosis. Currently, no effective medical treatments exist, with liver transplantation being the only life-extending option for advanced cases.

Related Experiment Videos

Last Updated: Jul 2, 2026

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma
05:22

Intraoperative Strategy under Complex Vascular Adhesion for Laparoscopic Radical Resection of Bismuth-Corlette Type IIIb Perihilar Cholangiocarcinoma

Published on: February 13, 2026

Area of Science:

  • Hepatology
  • Gastroenterology
  • Immunology

Background:

  • Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease.
  • It involves bile duct inflammation and fibrosis, leading to end-stage liver disease and reduced life expectancy.
  • PSC predominantly affects young to middle-aged men, often co-occurring with inflammatory bowel disease.

Purpose of the Study:

  • To provide a comprehensive overview of Primary Sclerosing Cholangitis (PSC).
  • To discuss the current understanding of PSC etiology, clinical presentation, and diagnostic hallmarks.
  • To review existing and emerging therapeutic strategies and management of PSC complications.

Main Methods:

  • Review of existing literature on Primary Sclerosing Cholangitis.
  • Analysis of diagnostic criteria including liver biochemistries and radiographic findings.
  • Evaluation of current treatment options and ongoing clinical studies.

Main Results:

  • PSC is characterized by elevated alkaline phosphatase, nonspecific autoantibodies, and a 'beaded' appearance on radiographic studies due to multifocal biliary strictures.
  • No definitive medical therapy is currently established, though high-dose ursodeoxycholic acid shows promise.
  • Liver transplantation is the sole life-extending therapy, but disease recurrence is possible.

Conclusions:

  • Primary Sclerosing Cholangitis (PSC) is a serious liver condition with significant morbidity and mortality.
  • Effective medical treatments are lacking, highlighting the need for further research and therapeutic development.
  • Management focuses on supportive care, complication management, and liver transplantation for end-stage disease.