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Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
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Published on: June 28, 2018

Ventilator-associated pneumonia caused by high risk microorganisms: a matched case-control study

Melda Aybar Türkoğlu1, Arzu Topeli Iskit

  • 1Medical Intensive Care Unit, Department of Internal Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. meldaturkoglu@yahoo.com.tr

Tuberkuloz Ve Toraks
|August 15, 2008
PubMed
Abstract

Insights

Ventilator-associated pneumonia (VAP) caused by high-risk microorganisms (HRM) significantly prolongs intensive care unit (ICU) and hospital stays. While not increasing mortality, HRM-VAP extends mechanical ventilation duration, impacting patient recovery.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Hospital Epidemiology

Background:

  • Ventilator-associated pneumonia (VAP) is a significant complication in intensive care units (ICUs).
  • High-risk microorganisms (HRM) are frequently implicated in VAP cases, potentially worsening patient outcomes.
  • Understanding the specific impact of HRM-VAP is crucial for optimizing patient management and resource allocation.

Purpose of the Study:

  • To determine the impact of VAP caused by high-risk microorganisms (HRM) on patient outcomes.
  • To assess the association between HRM-VAP and key clinical endpoints, including mortality, ICU length of stay, hospital length of stay, and duration of mechanical ventilation (MV).

Main Methods:

  • A matched case-control study was conducted in a university hospital's medical ICU.
  • Thirty-five patients with VAP caused by HRM (Pseudomonas aeruginosa, Acinetobacter spp., Stenotrophomonas maltophilia, MRSA) were matched with 35 control patients without VAP based on APACHE II score, age, admission date, and MV duration.
  • Outcomes including ICU and hospital mortality, length of ICU and hospital stay, and duration of MV were compared between cases and controls.

Main Results:

  • HRM-VAP was independently associated with prolonged ICU stay (OR: 6) and hospital stay (OR: 4).
  • Duration of mechanical ventilation was significantly longer in patients with HRM-VAP (OR: 11).
  • No significant association was found between HRM-VAP and ICU or hospital mortality rates.

Conclusions:

  • VAP caused by high-risk microorganisms is an independent risk factor for prolonged ICU and hospital stays, and extended mechanical ventilation.
  • HRM-VAP significantly increases the duration of resource utilization without a corresponding increase in mortality.
  • These findings highlight the importance of preventing and managing HRM-VAP to reduce patient morbidity and healthcare costs.

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