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Related Experiment Video

Updated: Jul 2, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas

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Published on: January 26, 2024

Circulating soluble endoglin and placental abruption.

Caroline Signore¹, James L Mills, Cong Qian

¹Division of Epidemiology, Statistics and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA.

Prenatal Diagnosis

|August 15, 2008

Summary

Serum soluble endoglin (sEng) levels are elevated before placental abruption and hypertension develop. These changes, indicating risk, appear in mid-pregnancy and continue throughout gestation.

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Area of Science:

Obstetrics and Gynecology
Maternal-Fetal Medicine
Reproductive Biology

Background:

Placental abruption is a leading cause of maternal and fetal morbidity.
Predictive biomarkers for placental abruption are crucial for timely intervention.
Soluble endoglin (sEng), an anti-angiogenic factor, has been implicated in pregnancy complications.

Purpose of the Study:

To investigate if serum concentrations of soluble endoglin (sEng) can predict placental abruption.
To determine the temporal relationship between sEng levels and the onset of placental abruption and hypertension.

Main Methods:

A nested case-control study design was employed.
Serum samples from 31 nulliparous women with placental abruption and 31 controls were analyzed.
sEng levels were measured prospectively before the onset of hypertension or abruption, across three gestational age intervals.

Main Results:

No significant difference in sEng was observed in early pregnancy.
sEng levels were significantly elevated in cases of placental abruption between 21-32 weeks gestation.
In women who developed both hypertension and placental abruption, sEng was significantly increased in mid and late pregnancy.

Conclusions:

Elevated serum sEng precedes the clinical diagnosis of hypertension and placental abruption.
sEng elevations become apparent in the late second trimester and persist.
sEng may serve as a valuable predictive biomarker for identifying pregnant women at risk for placental abruption and hypertension.