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Updated: Jul 2, 2026

Olfactory Assays for Mouse Models of Neurodegenerative Disease
07:27

Olfactory Assays for Mouse Models of Neurodegenerative Disease

Published on: August 25, 2014

Olfactory deficits in mice overexpressing human wildtype alpha-synuclein

Sheila M Fleming1, Nicole A Tetreault, Caitlin K Mulligan

  • 1Department of Neurology and Neurobiology, The David Geffen School of Medicine at UCLA, 710 Westwood Plaza, Los Angeles, CA 90095-1769, USA. sfleming@ucla.edu

The European Journal of Neuroscience
|August 16, 2008
PubMed
Summary

Overexpression of alpha-synuclein in mice causes olfactory deficits, mimicking early Parkinson's disease (PD) symptoms. These mice and tests are valuable for developing new PD neuroprotective therapies.

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The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...