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Related Experiment Video

Updated: Jul 2, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Comorbidity in posttraumatic stress disorder: a structural equation modelling approach.

Lutz Wittmann¹, Hanspeter Moergeli, Chantal Martin-Soelch

¹Department of Psychiatry, University Hospital, CH-8091 Zurich, Switzerland. lutz.wittmann@usz.ch

Comprehensive Psychiatry

|August 16, 2008

Summary

This study examined posttraumatic stress disorder (PTSD) comorbidity in accident survivors. Integrating models of PTSD and health satisfaction best explains comorbid symptoms, highlighting the need for comprehensive approaches.

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Last Updated: Jul 2, 2026

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Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Biomarkers in an Animal Model for Revealing Neural, Hematologic, and Behavioral Correlates of PTSD

Published on: October 10, 2012

Area of Science:

Psychiatry
Trauma Studies
Mental Health Research

Background:

Posttraumatic stress disorder (PTSD) frequently co-occurs with other psychiatric conditions.
Current theories explain comorbidity as a PTSD consequence, due to shared vulnerabilities, or trauma-specific factors.

Purpose of the Study:

To compare the explanatory power of three distinct theoretical models of psychiatric comorbidity.
To investigate the interplay between PTSD, sense of coherence, health satisfaction, and comorbid symptoms in accident survivors.

Main Methods:

Assessed PTSD, sense of coherence, health satisfaction, anxiety, and depression symptoms in 225 injured accident survivors at 5 days (t1) and 6 months (t2) post-accident.
Utilized structural equation modeling to test three theoretical models, both individually and in combination.

Main Results:

A combined model integrating PTSD and health satisfaction best explained 82% of the variance in comorbid symptoms at 6 months post-accident.
Both PTSD and satisfaction with health at 6 months significantly influenced the development of comorbid symptoms.

Conclusions:

Psychiatric comorbidity, beyond PTSD itself, is most effectively understood through an integrated approach combining multiple explanatory models.
This suggests that interventions should consider both PTSD-specific and broader health-related factors.