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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Related Experiment Video

Updated: Jul 2, 2026

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

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Published on: July 19, 2019

Grey matter pathology in multiple sclerosis.

Jeroen J G Geurts1, Frederik Barkhof

  • 1Department of Radiology, VU University Medical Centre, Amsterdam, Netherlands. j.geurts@vumc.nl

The Lancet. Neurology
|August 16, 2008
PubMed
Summary

Multiple sclerosis (MS) involves grey matter damage, impacting cognitive function. New research explores potential causes like inflammation and neuronal vulnerability, challenging traditional views of this neurological disease.

Area of Science:

  • Neurology
  • Neuroimmunology
  • Neurodegeneration

Background:

  • Multiple sclerosis (MS) was traditionally viewed as a white matter disease.
  • Emerging evidence highlights significant grey matter involvement in MS pathogenesis.
  • Grey matter damage in MS correlates with impaired clinico-cognitive function.

Purpose of the Study:

  • To review current understanding of grey matter damage in MS.
  • To explore novel hypotheses regarding the pathogenesis of grey matter lesions.
  • To discuss the implications of these findings for MS diagnosis and treatment.

Main Methods:

  • Review of recent histopathological studies on MS.
  • Analysis of advanced MRI techniques for detecting grey matter lesions.

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  • Synthesis of emerging hypotheses on grey matter pathogenesis.

    • Main Results:

    • Cortical grey matter is significantly affected in MS, starting early in the disease.
    • Standard MRI techniques face challenges in detecting cortical grey matter lesions.
    • Several new hypotheses for grey matter damage are proposed, including meningeal inflammation and selective neuronal vulnerability.

    Conclusions:

    • Grey matter pathology is a critical component of MS, impacting cognitive outcomes.
    • Advanced imaging techniques are necessary for accurate detection of grey matter lesions.
    • Further research is needed to validate proposed pathogenic mechanisms, potentially reshaping MS understanding.