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A System to Create Stable Nanoparticle Aerosols from Nanopowders

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Microscale granulation in a fluid bed powder processor using electrostatic atomisation.

N Kivikero¹, M Murtomaa, B Ingelbeen

¹Industrial Pharmacy, University of Helsinki, Finland. niina.kivikero@helsink.fi

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V

|August 16, 2008

Summary

This summary is machine-generated.

This study explored electrostatic atomisation in microscale fluid bed granulation. Higher liquid flow rates and atomisation voltage increased granule size, while binder concentration effects were unclear.

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Area of Science:

Pharmaceutical technology
Chemical engineering
Materials science

Background:

Microscale fluid bed granulation is crucial for pharmaceutical development.
Electrostatic atomisation offers potential for precise control in granulation.
Understanding process parameters is key to optimizing granule properties.

Purpose of the Study:

To investigate the impact of electrostatic atomisation parameters on microscale fluid bed granulation.
To define the effects of granulation liquid flow rate, atomisation voltage, and binder concentration.
To analyze granule size distribution resulting from these process variations.

Main Methods:

Utilized electrostatic atomisation within a miniaturised fluid bed granulation process.
Conducted 22 granulation batches using the Multichamber Microscale Fluid bed powder Processor (MMFP).
Measured granule size distributions via sieving and image analysis.

Main Results:

Atomisation liquid flow rate showed a strong positive correlation with increased granule size.
Elevated atomisation voltage unexpectedly led to larger granule sizes.
The influence of binder concentration on granule size was inconclusive.

Conclusions:

Electrostatic atomisation parameters significantly affect microscale granulation outcomes.
Principal component analysis (PCA) aids in understanding complex microscale granulation phenomena.
Further research is needed to clarify the role of binder concentration and optimize the process.