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Updated: Jul 2, 2026

Isolation of Atrial Myocytes from Adult Mice
Published on: July 25, 2019
B-type natriuretic peptide is related to histological skeletal muscle abnormalities in patients with chronic heart
Alf Inge Larsen1, Øyvind Skadberg, Torbjørn Aarsland
1Department of Cardiology, Stavanger University Hospital, Norway. laai@sus.no
Abstract:
This study examined the potential association between skeletal muscle histological findings and circulating levels of N-terminal Atrial natriuretic peptide (NT-proANP) and N-terminal B-type natriuretic peptide (NT-proBNP) at rest and during exercise in patients with moderate chronic heart failure. We report a significant correlation between muscle fibre roundness, defined as ratio of fibre perimeter squared to fibre area, and plasma levels of N-BNP. This finding suggests that the degree of intrafibrillar edema is related to the secretion of NT-proBNP.
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