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Updated: Jul 2, 2026
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
[Proteinuria and renal transplantation]
1Service de néphrologie A1-Transplantation adultes, Hôpital Necker-Enfants malades, 149, rue de Sèvres, 75743 Paris cedex 15, France. christophe.legendre@nck.ap-hop-paris.fr
Nephrologie & Therapeutique
|September 26, 2008
Summary
Proteinuria in transplant patients signals poor prognosis, increasing risks of death and graft loss. High-dose sirolimus can induce proteinuria, impacting kidney function and graft survival.
Area of Science:
- Nephrology
- Transplantation Medicine
- Pharmacology
Context:
- Proteinuria is a significant negative prognostic marker in kidney transplant recipients.
- Both low-level proteinuria and increased albuminuria correlate with higher risks of graft loss and patient mortality.
- Early detection of proteinuria (1-3 months post-transplant) is crucial for graft survival.
Purpose:
- To investigate the prognostic significance of proteinuria in transplant patients.
- To evaluate the impact of different levels of albuminuria on graft and patient survival.
- To explore the role of sirolimus in the induction of proteinuria.
Summary:
- Proteinuria, even at low levels (0.5 g/d), significantly reduces graft survival.
- Macro-albuminuria drastically increases risks of graft loss (16.4x) and death (4.12x) compared to normo-albuminuria.
- Sirolimus, particularly at high doses, can induce reversible proteinuria with potential partial renal function recovery.
Impact:
- Proteinuria assessment is vital for predicting outcomes in kidney transplant patients.
- Understanding sirolimus-induced proteinuria aids in managing immunosuppression and preventing graft complications.
- Findings highlight the need for monitoring urinary protein excretion in patients on sirolimus therapy.
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