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Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

Published on: October 23, 2015

A novel three-phase model of brain tissue microstructure.

Jana L Gevertz¹, Salvatore Torquato

¹Program in Applied and Computational Mathematics, Princeton University, Princeton, New Jersey, United States of America.

Plos Computational Biology

|August 16, 2008

Summary

A new three-phase brain model reveals limitations of two-phase models for accurately representing brain microstructure. Incorporating the extracellular matrix is crucial for realistic diffusion coefficient calculations in brain tissue.

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3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

3D Modeling of the Lateral Ventricles and Histological Characterization of Periventricular Tissue in Humans and Mouse

Published on: May 19, 2015

Area of Science:

Neuroscience
Biophysics
Materials Science

Background:

Existing two-phase models of brain microstructure, packing cells in extracellular space, are insufficient.
These models fail to preserve realistic geometric/topological features or overestimate effective diffusivity.
The extracellular matrix's role in brain tissue diffusivity requires further investigation.

Purpose of the Study:

To develop a novel, biologically constrained three-phase model of brain microstructure.
To assess the adequacy of existing two-phase models.
To investigate the contribution of the extracellular matrix to brain tissue diffusivity.

Main Methods:

Application of techniques from random heterogeneous materials theory.
Analysis of geometric and topological features of brain tissue.
Utilizing first-passage-time techniques to model diffusion.

Main Results:

Two-phase models are insufficient for accurately representing brain microstructure.
A three-phase model incorporating the extracellular matrix provides a more realistic representation.
The extracellular matrix significantly reduces the diffusion coefficient, aligning with biological constraints.

Conclusions:

A three-phase model is necessary for a biologically constrained representation of brain microstructure.
The extracellular matrix plays a critical role in regulating brain tissue diffusivity.
This model offers a more accurate approach to understanding brain tissue properties.