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Preliminary analysis of the new 'Prenatal Risk Calculation (PRC)' software
Cindy Hörmansdörfer1, A Scharf, M Golatta
1Department of Obstetrics and Gynaecology, Medical University of Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. cinsanchez@hotmail.com
Archives of Gynecology and Obstetrics
|August 16, 2008
Summary
The Prenatal risk calculation (PRC) software showed significant aneuploidy detection in first trimester screening (FTS). However, it performed significantly worse than JOY software, with a higher false-positive rate, suggesting a need for revision.
Area of Science:
- Medical diagnostics
- Prenatal screening
- Genetics
Background:
- The Fetal Medicine Foundation Germany introduced new calculation software, Prenatal risk calculation (PRC), in 2007.
- First Trimester Screening (FTS) is a crucial method for detecting fetal aneuploidies.
Purpose of the Study:
- To retrospectively evaluate the test performance of PRC.
- To compare PRC's performance against the JOY software's NT module for FTS.
Main Methods:
- Analysis of 3,516 combined FTS cases (11-14 weeks gestation).
- Risk calculation for aneuploidy using both PRC and JOY software.
- Comparison of sensitivity, false-positive rate, and positive predictive value.
Main Results:
- JOY software demonstrated superior test performance compared to PRC.
- At a 1:300 cut-off, JOY had 82.4% sensitivity and 3.6% FPR, while PRC had 76.5% sensitivity and 7.1% FPR.
- These performance differences were statistically significant (P<0.0001).
Conclusions:
- PRC showed significant aneuploidy detection but was inferior to JOY.
- PRC's higher false-positive rate could lead to increased unnecessary invasive testing.
- A revision of the PRC software is recommended.
