Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Epigenetic Regulation

Epigenetic Regulation

Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...

Epigenetic Regulation

Epigenetic Regulation

Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Prognostic Significance of Pretreatment Blood-Based Biomarkers in Penile Cancer: A Multicenter Retrospective Study in Japan.

International journal of urology : official journal of the Japanese Urological Association·2026

Same author

Impact of treatment volume on outcomes for patients with penile cancer at relatively low-volume centers in Japan.

Japanese journal of clinical oncology·2026

Same author

Circulating Tumor DNA Genomic Profiling in <sup>223</sup>Ra-Treated Metastatic Castration-Resistant Prostate Cancer: The KYUCOG-1901 Study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2026

Same author

Impact of radium-223 on bone imaging and biochemical markers with and without bone-modifying agents in bone-metastatic castration-resistant prostate cancer: results from the kyucog-1901 study.

European journal of nuclear medicine and molecular imaging·2026

Same author

Clinical Outcomes and Clinicopathological Features of Primary Urethral Carcinoma: A Multicenter Retrospective Study in Japan.

International journal of urology : official journal of the Japanese Urological Association·2026

Same author

Therapeutic strategies for MMAE-resistant bladder cancer through DPP4 inhibition.

Molecular oncology·2025

Same journal

Three-month follow-up of high-dose intravenous iron monotherapy for cancer-related anemia in an ESA-free oncology setting: a real-world cohort study.

International journal of clinical oncology·2026

Same journal

Cumulative multidisciplinary team messages and home death after palliative care unit discharge in advanced cancer: a prospective regional implementation cohort study.

International journal of clinical oncology·2026

Same journal

Association between response to gemcitabine-based neoadjuvant therapy and efficacy of gemcitabine plus nab-paclitaxel for recurrent pancreatic ductal adenocarcinoma.

International journal of clinical oncology·2026

Same journal

Relationships of serum cabozantinib concentration with tumor response and adverse events in treatment of advanced renal cell carcinoma: observational exploratory prospective study.

International journal of clinical oncology·2026

Same journal

Impact of periodontitis on the efficacy of neoadjuvant immunochemotherapy in non-small cell lung cancer: a multi-center real-world study.

International journal of clinical oncology·2026

Same journal

Phase I study of glofitamab in Japanese patients with relapsed or refractory B-cell non-Hodgkin lymphoma.

International journal of clinical oncology·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jul 2, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Epigenetics in bladder cancer.

Hideki Enokida¹, Masayuki Nakagawa

¹Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, Japan. enokida@m.kufm.kagoshima-u.ac.jp

International Journal of Clinical Oncology

|August 16, 2008

Summary

This summary is machine-generated.

Epigenetic changes like DNA methylation are crucial in bladder cancer (BC) development. Targeting these reversible epigenetic aberrations offers new diagnostic and therapeutic strategies for BC.

Related Experiment Videos

Last Updated: Jul 2, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

An Orthotopic Bladder Cancer Model for Gene Delivery Studies

Published on: December 1, 2013

Area of Science:

Oncology
Epigenetics
Molecular Biology

Background:

Bladder cancer (BC) is a significant genitourinary malignancy with high mortality.
Epigenetic mechanisms, including DNA methylation and histone modifications, are vital in gene regulation and cancer progression.
Aberrant epigenetic events, such as DNA hypermethylation and altered histone acetylation, are prevalent in bladder cancer, impacting numerous genes.

Purpose of the Study:

To review the current literature on epigenetic alterations in bladder cancer.
To discuss the clinical potential of cancer epigenetics for BC diagnosis and treatment.

Main Methods:

Literature review of epigenetic changes in bladder cancer.
Analysis of aberrant DNA methylation and histone modifications in BC.
Examination of epigenetic modulators for BC treatment.

Main Results:

Epigenetic dysregulation is widespread in bladder cancer.
Combination analysis of epigenetically altered genes shows promise for BC biomarkers.
Epigenetic aberrations are reversible and targetable for therapeutic intervention.

Conclusions:

Epigenetic modifications play a critical role in bladder cancer initiation and progression.
Identifying bladder cancer-specific epigenetic fingerprints through large-scale screening is essential.
Epigenetic therapies targeting DNA demethylation and histone deacetylase inhibition hold significant clinical potential for BC treatment.