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Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Intra-Cardiac Injection of Human Prostate Cancer Cells to Create a Bone Metastasis Xenograft Mouse Model

Published on: November 4, 2022

Cardiac metastases.

Abrahim Al-Mamgani¹, Lizette Baartman, Margreet Baaijens

¹Department of Radiation Oncology, Erasmus MC-Daniel den Hoed Cancer Center, Groene Hilledijk 301, Rotterdam, The Netherlands. a.al-mamgani@erasmusmc.nl

International Journal of Clinical Oncology

|August 16, 2008

Summary

This summary is machine-generated.

Esophageal cancer can spread to the heart, causing symptoms. Short-course radiotherapy provided good relief for a patient with cardiac metastases, highlighting its role in managing this condition.

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Area of Science:

Oncology
Cardiology
Radiotherapy

Background:

Cardiac metastases are rare but serious complications of cancer.
Esophageal cancer is a known primary tumor that can metastasize to the heart.

Observation:

Autopsy studies from 1975-2007 show cardiac metastases incidence of 2.3% in general population and 7.1% in cancer patients.
A significant increase in cardiac metastases incidence was observed in cancer patients diagnosed after 1970 (7.1%) compared to earlier series (3.8%).

Findings:

Radiotherapy can effectively manage symptomatic cardiac metastases.
A case of esophageal cancer with symptomatic cardiac metastases was successfully treated with short-course radiotherapy, achieving good symptomatic relief.

Implications:

The findings suggest an increasing trend of cardiac metastases, necessitating improved diagnostic and therapeutic strategies.
Radiotherapy should be considered a valuable treatment option for symptomatic cardiac metastases, improving patient outcomes and quality of life.