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A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Hypercholesterolemia and prostate cancer: a hospital-based case-control study.
Lindsay Magura1, Richelle Blanchard, Brian Hope
1School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND 58102, USA.
Cancer Causes & Control : CCC
|August 16, 2008
Summary
High cholesterol levels may increase prostate cancer risk in white men. This hospital-based study found a link between hypercholesterolemia and increased odds of developing prostate cancer.
Area of Science:
- Oncology
- Epidemiology
- Cardiovascular Health
Background:
- Elevated serum cholesterol has been suspected to increase prostate cancer risk.
- Existing epidemiologic evidence linking cholesterol and prostate cancer is limited.
Purpose of the Study:
- To investigate the association between hypercholesterolemia and prostate cancer.
- To examine the relationship between lipid profiles and prostate cancer risk.
Main Methods:
- A hospital-based case-control study was conducted in Fargo, ND.
- Cases were men with confirmed prostate cancer; controls were men without cancer undergoing physical exams.
- Demographic and clinical data were extracted from medical records.
Main Results:
- Hypercholesterolemia (total cholesterol > 5.17 mmol/l) was significantly associated with prostate cancer (OR=1.58).
- Low HDL and high LDL cholesterol levels were also linked to increased prostate cancer risk.
- Current smokers had a significantly higher risk (OR=1.84) compared to never smokers.
Conclusions:
- This study provides further evidence suggesting hypercholesterolemia may elevate prostate cancer risk in white men.
- The findings support the potential role of cholesterol management in prostate cancer prevention strategies.
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