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Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
New Flavonoids from Boldoa purpurascens Cav
Dulce María Mosquera1, Amuri Kilonda, Suzanne Toppet
1Department of Pharmacy at Marta Abreu University, Road to Camajuani, Santa Clara, Cuba.
Planta Medica
|August 16, 2008
Summary
Phytochemical analysis of Boldoa purpurascens leaves identified three new flavone glycosides. These compounds, along with a known one, were tested for antifungal activity but showed no efficacy against tested fungal strains.
Area of Science:
- Phytochemistry
- Natural Products Chemistry
- Organic Chemistry
Background:
- Boldoa purpurascens is a plant species with potential medicinal properties.
- Flavonoid glycosides are a class of natural compounds known for diverse biological activities.
- Understanding the phytochemical profile of medicinal plants is crucial for drug discovery.
Purpose of the Study:
- To isolate and characterize phytochemicals from the leaves of Boldoa purpurascens.
- To identify novel compounds and determine their chemical structures.
- To evaluate the antifungal activity of the isolated compounds.
Main Methods:
- Phytochemical analysis of plant extracts.
- Isolation of compounds using chromatographic techniques.
- Structure elucidation using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy (1D and 2D).
- Antifungal activity testing against Fusarium culmorum, Botrytis cinerea, and Aspergillus flavus.
Main Results:
- Four flavone glycosides were isolated from Boldoa purpurascens leaves.
- Three of the isolated flavone glycosides are new chemical entities.
- The structures of the new compounds were determined as 4',5-dihydroxy-6,7-methylenedioxyflavonol 3- O-alpha- L-rhamnopyranosyl-(1-->2)-beta- D-xylopyranoside (1), 4',5-dihydroxy-6,7-methylenedioxyflavonol 3- O-beta- D-xylopyranoside (2), and 4',5-dihydroxy-6,7-methylenedioxyflavonol 3- O-alpha- L-rhamnopyranosyl-(1-->2)-beta- D-glucopyranoside (3).
- The known compound identified was 4',5-dihydroxy-6,7-methylenedioxyflavonol 3- O-beta- D-glucopyranoside (4).
- The aglycone, gomphrenol (4',5-dihydroxy-6,7-methylenedioxyflavonol), was also identified.
- Compounds 1 and 2 exhibited no antifungal activity against the tested fungal strains.
Conclusions:
- The phytochemical investigation of Boldoa purpurascens yielded three new flavone glycosides.
- The isolated compounds, including the new ones, did not demonstrate significant antifungal properties against the tested fungal pathogens.
- Further research may explore other biological activities or different chemical modifications of these compounds.
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