Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Obtaining S values for rectangular-solid tumors inside rectangular-solid host organs.

T G Stinchcomb1, J S Durham, D R Fisher

  • 1Department of Physics, DePaul University, Chicago, Illinois 60614.

Medical Physics
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of a walnut-rich breakfast on cognitive performance and brain activity throughout the day in healthy young adults: a crossover intervention trial.

Food & function·2025
Same author

ICRP Publication 140: Radiological Protection in Therapy with Radiopharmaceuticals.

Annals of the ICRP·2019
Same author

Effect of di-n-propylacetate and γ-acetylenic GABA on hyperbaric oxygen-induced seizures and GABA metabolism.

Neurochemical research·2013
Same author

Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract.

Journal of Alzheimer's disease : JAD·2007
Same author

Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract.

Journal of Alzheimer's disease : JAD·2006
Same author

Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes.

Journal of Alzheimer's disease : JAD·2006
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

This study introduces MTUMOR, a method to calculate S values for radiation dosimetry between tumors and organs using the Medical Internal Radiation Dose (MIRD) formalism. It enables more precise internal radiation dose assessments in nuclear medicine.

Area of Science:

  • Medical Physics
  • Nuclear Medicine
  • Radiation Dosimetry

Background:

  • Accurate internal radiation dosimetry is crucial for effective nuclear medicine therapies.
  • The Medical Internal Radiation Dose (MIRD) formalism is a standard for calculating absorbed doses.
  • Calculating S values (dose per unit cumulated activity) between specific tissues like tumors and organs can be complex.

Purpose of the Study:

  • To develop and describe a computational method (MTUMOR) for determining S values between a tumor and its host organ.
  • To adapt existing point-source specific absorbed fractions for use with arbitrary rectangular geometries.
  • To integrate this method with the widely used MIRDOSE program for practical application.

Main Methods:

  • Applied Berger's point-source specific absorbed fractions for water to rectangular volumes representing tumors and organs.

Related Experiment Videos

  • Summed contributions from source and target volume elements to calculate S values.
  • Utilized the reciprocity theorem for inter-organ dose calculations.
  • Interfaced the MTUMOR method with the MIRDOSE program.

    • Main Results:

    • Successfully developed a method (MTUMOR) to compute S values for tumor-host organ dosimetry.
    • Demonstrated the application of the method using an example calculation.
    • Provided a means to calculate S values between a tumor and itself, the host organ and itself, and between the tumor and the host organ.

    Conclusions:

    • The MTUMOR method provides a practical approach for calculating S values in tumor-specific dosimetry.
    • This method enhances the capabilities of the MIRD formalism for internal radiation dose assessment.
    • Integration with MIRDOSE facilitates its use in clinical and research settings.