[Determination of the arterial input function in mouse-models using clinical MRI].
Dorothea Theis1, Boris Keil, Johannes T Heverhagen
1Klinik für Strahlendiagnostik, Philipps-Universität Marburg, Marburg. dorothea.theis@gmail.com
Zeitschrift Fur Medizinische Physik
|August 19, 2008
Summary
Dynamic contrast-enhanced MRI helps quantify tumor perfusion in animal models. Measuring the arterial input function (AIF) directly in each animal is crucial due to significant variability, ensuring accurate cancer research.
Area of Science:
- Biomedical Imaging
- Pharmacokinetics
- Cancer Research
Context:
- Dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) is vital for assessing tumor perfusion in preclinical cancer studies.
- Accurate determination of the arterial input function (AIF) is a critical first step in quantitative DCE-MRI analysis.
- Small animal models are increasingly used to study cancer, requiring precise physiological measurements.
Purpose:
- To determine the native T1 relaxation times and arterial input function (AIF) in mice using DCE-MRI.
- To evaluate the reliability of a proposed method for AIF determination in small animal models.
- To highlight the necessity of direct AIF measurement due to inter-animal variability.
Summary:
- A method was developed to determine the arterial input function (AIF) from left ventricle signal intensity changes during Gd-DTPA administration in mice.
- Native T1 relaxation times averaged (1.16+/-0.09) s.
- Significant inter-animal variability in AIF was observed, confirming the need for direct measurement to minimize errors.
Impact:
- The study validates a reliable method for determining AIF in small animal models, crucial for accurate tumor perfusion quantification.
- This work supports the advancement of quantitative DCE-MRI in preclinical cancer research.
- Improved accuracy in AIF measurement can lead to more effective drug development and treatment strategies in oncology.
