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Related Experiment Video

Updated: Jul 2, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Maxillary sinus floor elevation using a tissue-engineered bone complex with OsteoBone and bMSCs in rabbits.

X-Juan Sun1, Z-Yuan Zhang, S-Yi Wang

  • 1Department of Oral and Maxillofacial Surgery, School of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Clinical Oral Implants Research
|August 19, 2008
PubMed
Summary

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Tissue-engineered bone complex using OsteoBone and bone marrow stromal cells (bMSCs) effectively promotes new bone formation in rabbit maxillary sinus floor elevation. This combination maintained augmented height, unlike traditional methods.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Oral and Maxillofacial Surgery

Background:

  • Maxillary sinus floor elevation is crucial for dental implant placement.
  • Grafting materials are needed to augment bone height.
  • Tissue-engineered bone offers a promising alternative.

Purpose of the Study:

  • To evaluate OsteoBone combined with bone marrow stromal cells (bMSCs) for maxillary sinus floor elevation in rabbits.
  • To compare this combination with OsteoBone alone, autogenous bone, and blood clot.

Main Methods:

  • Autologous bMSCs were cultured and combined with OsteoBone.
  • Maxillary sinus floor elevation surgeries were performed in rabbits.
  • Histological and histomorphometric analyses were conducted at 2, 4, and 8 weeks.

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Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

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Last Updated: Jul 2, 2026

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
08:41

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials

Published on: August 13, 2019

Biological Compatibility Profile on Biomaterials for Bone Regeneration
10:28

Biological Compatibility Profile on Biomaterials for Bone Regeneration

Published on: November 16, 2018

Main Results:

  • The OsteoBone + bMSCs group showed increased bone area and maintained augmented height.
  • OsteoBone alone also demonstrated bone growth.
  • Autogenous bone and blood clot groups showed decreased bone area and height, with fatty tissue infiltration.

Conclusions:

  • OsteoBone is a viable bone graft substitute for sinus elevation.
  • Combining OsteoBone with bMSCs significantly enhances new bone formation and height maintenance.
  • This approach holds potential for improving bone augmentation outcomes.