Related Experiment Video
Updated: Jul 2, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Tenofovir: what have over 1 million years of patient experience taught us?
1Chelsea and Westminster Hospital, Department of HIV/GU Medicine, London, UK. anton.pozniak@chelwest.nhs.uk
Abstract:
Several groundbreaking trials and over 1 million years of patient experience have established tenofovir as an important component of HIV treatment. Tenofovir has demonstrated potent antiviral efficacy, with a low risk of developing resistance when used as part of an effective combination regimen. It is generally well tolerated, with a low risk of lipoatrophy and a favourable effect on lipid profile compared with older nucleoside analogue agents such as stavudine or zidovudine. Clinical data suggest that switching from thymidine analogues to a tenofovir-containing regimen can benefit patients with lipid abnormalities or lipoatrophy. This article reviews the development of tenofovir, including pivotal studies that have influenced HIV clinical practice.
More Related Videos
Related Concept Videos
Antiviral Nucleoside Inhibitors
Retrovirus Life Cycles
Retroviruses
Therapeutic Drug Monitoring: Affecting Factors
Inhibitors of Viral Protein Synthesis
Viral Hepatitis I: Introduction

