Related Experiment Video

Updated: Jul 2, 2026

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
09:41

Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage

Published on: July 3, 2014

Recent research on changes in genomic regulation and protein expression in intracerebral haemorrhage

Jason R Cannon1, Guohua Xi, Richard F Keep

  • 1Department of Neurology, Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, Pittsburgh, PA 15260, USA. cannonjr@upmc.edu

International Journal of Stroke : Official Journal of the International Stroke Society
|August 19, 2008
PubMed

Insights

Intracerebral haemorrhage (ICH) causes severe brain injury with no current therapy. This review details gene and protein expression changes post-ICH, exploring their impact on brain injury progression in humans and animals.

Area of Science:

  • Neuroscience
  • Genetics
  • Molecular Biology

Background:

  • Intracerebral haemorrhage (ICH) is a severe stroke subtype, often leading to significant disability.
  • Currently, no effective treatments exist for ICH, highlighting a critical unmet medical need.

Purpose of the Study:

  • To review current knowledge on genetic and protein expression alterations following ICH.
  • To explore how these molecular changes influence the progression of brain injury after ICH.

Main Methods:

  • Comprehensive review of existing scientific literature.
  • Analysis of both animal models and human studies related to ICH.

Main Results:

  • ICH triggers significant changes in gene and protein expression within the brain.
  • These molecular alterations are implicated in the secondary injury cascade following haemorrhage.

Conclusions:

  • Understanding ICH-induced molecular changes is crucial for developing targeted therapies.
  • Further research into these genetic and protein expression patterns may reveal novel therapeutic strategies for stroke.

More Related Videos

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury09:29

Stereotactic Atlas-Guided Laser Capture Microdissection of Brain Regions Affected by Traumatic Injury

Published on: September 11, 2017

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model08:18

Intracranial Pressure Monitoring In Nontraumatic Intraventricular Hemorrhage Rodent Model

Published on: February 8, 2022

Related Concept Videos

Hemorrhagic Stroke ll: Pathophysiology01:29

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...
Hemorrhagic Stroke l: Introduction01:17

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...