Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
Acute Coronary Syndrome IV: Interprofessional Care01:28

Acute Coronary Syndrome IV: Interprofessional Care

IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.
Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care01:29

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tirofiban and thrombectomy for acute ischaemic stroke.

Lancet (London, England)·2026
Same author

Disparities in Prehospital Stroke Care: Neighbourhood Socioeconomic Status and Delays in Hospital Presentation.

Cerebrovascular diseases (Basel, Switzerland)·2026
Same author

Mapping the mRS Into the EQ-5D-5L in Patients With Ischemic Stroke.

Stroke·2026
Same author

Endovascular treatment in patients with renal dysfunction: results of the MR CLEAN Registry.

European stroke journal·2026
Same author

Imaging Modalities to Visualize Deep Cerebral Perforating Arteries: A Systematic Review and Meta-analysis.

AJNR. American journal of neuroradiology·2026
Same author

Validity of intracerebral haemorrhage volume assessment: comparison of fully automated segmentation analysis with manual ABC/2 and semi-automated measurement.

European stroke journal·2026

Related Experiment Video

Updated: Jul 2, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Promoting Acute Thrombolysis for Ischaemic Stroke (PRACTISE).

Maaike Dirks1, Louis W Niessen, Robbert Huijsman

  • 1Department of Neurology, Erasmus MC University Hospital Rotterdam, Rotterdam, The Netherlands. m.dirks@erasmusmc.nl

International Journal of Stroke : Official Journal of the International Stroke Society
|August 19, 2008
PubMed
Summary

A high-intensity strategy significantly improves thrombolysis rates for acute ischemic stroke patients. This approach addresses barriers to implementing this effective treatment, enhancing patient outcomes.

More Related Videos

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Related Experiment Videos

Last Updated: Jul 2, 2026

Prehospital Thrombolysis: A Manual from Berlin
05:52

Prehospital Thrombolysis: A Manual from Berlin

Published on: November 26, 2013

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
09:21

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke

Published on: January 18, 2018

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide
09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

Area of Science:

  • Neurology
  • Public Health
  • Healthcare Implementation Science

Background:

  • Intravenous recombinant tissue plasminogen activator (rtPA) is a critical treatment for acute ischemic stroke within 3 hours of symptom onset.
  • Despite over 20% of stroke patients being eligible, actual treatment rates remain low (1-8%) due to various implementation barriers.
  • Barriers include inter-organizational, intra-organizational, medical, and psychological factors hindering widespread thrombolysis adoption.

Purpose of the Study:

  • To assess the impact of a high-intensity implementation strategy for intravenous thrombolysis in acute ischemic stroke compared to standard care.
  • To identify key success factors and obstacles encountered during the implementation process.
  • To evaluate the cost-effectiveness of the high-intensity strategy, including implementation costs.

Main Methods:

  • A national cluster-randomized controlled trial (PRACTISE study) involving 12 hospitals.
  • Hospitals were pair-matched and randomly assigned to either regular or high-intensity implementation groups.
  • The high-intensity intervention included training based on the Breakthrough model and a comprehensive toolkit.

Main Results:

  • The primary outcome was the rate of thrombolysis treatment.
  • Secondary outcomes included timely admission (within 4 hours), 3-month mortality or disability, hemorrhagic complications, and overall costs.
  • Tertiary outcomes focused on organizational aspects like door-to-needle time and protocol adherence to monitor implementation effectiveness.

Conclusions:

  • The study provides crucial data on the effectiveness and cost-effectiveness of actively implementing established acute ischemic stroke treatments.
  • The multifaceted nature of the intervention complicates attributing outcomes to specific components.
  • Monitoring intermediate outcomes and specific implementation tasks offers insights into factors driving successful thrombolysis implementation and acute intervention effectiveness.