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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Group Polarization

Group polarization is the strengthening of an original group attitude following the discussion of views within a group (Teger & Pruitt, 1967). That is, if a group initially favors a viewpoint, after discussion the group consensus is likely a stronger endorsement of the viewpoint. Conversely, if the group was initially opposed to a viewpoint, group discussion would likely lead to stronger opposition.
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Related Experiment Video

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Inducing Polyp Bail-out in Coral Colonies to Obtain Individualized Micropropagates for Laboratory Experimental Use
07:23

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Polypill: for Pollyanna.

J David Spence1

  • 1Stroke Prevention & Atherosclerosis Research Centre, Robarts Research Institute, London, ON, Canada. dspence@robarts.ca

International Journal of Stroke : Official Journal of the International Stroke Society
|August 19, 2008
PubMed
Summary
This summary is machine-generated.

A proposed single pill for cardiovascular disease prevention in individuals over 55 faces significant challenges. Individualized patient needs, adverse effects, and drug interactions make a one-size-fits-all approach inappropriate.

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Area of Science:

  • Cardiovascular medicine
  • Pharmacology
  • Preventive cardiology

Background:

  • A combination pill including statin, thiazide diuretic, beta-blocker, angiotensin receptor antagonist, folate, and aspirin (ASA) was proposed for all individuals over 55.
  • The aim was to achieve an 80% reduction in cardiovascular disease (CVD).

Purpose of the Study:

  • To evaluate the feasibility and appropriateness of a single-pill approach for CVD prevention in the elderly population.
  • To identify the challenges associated with a universal fixed-dose combination therapy.

Main Methods:

  • Conceptual analysis of a proposed fixed-dose combination therapy for cardiovascular disease prevention.
  • Review of potential adverse effects, drug interactions, and pharmacokinetic variability.

Main Results:

  • Significant challenges exist in selecting appropriate drug combinations for a universal pill.
  • Inter-individual variations in drug metabolism and diverse etiological factors of hypertension necessitate personalized treatment strategies.
  • Potential for adverse drug events and interactions is high in a broad, unselected population.

Conclusions:

  • A single-pill strategy for cardiovascular disease prevention in individuals over 55 is conceptually and practically inappropriate.
  • Individualized pharmacotherapy remains the optimal approach for managing cardiovascular risk factors and preventing disease.
  • Personalized medicine is crucial due to patient-specific factors like drug metabolism and underlying disease causes.