Related Experiment Video
Updated: Jul 2, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
Published on: May 17, 2024
[Composite pheochromocytoma associated with multiple endocrine neoplasia type 2B]
Slim Charfi1, Lobna Ayadi, Sameh Ellouze
1Laboratoire d'anatomie et de cytologie pathologique, CHU Habib-Bourguiba, rue El-Ain, 3029 Sfax, Tunisia.
Abstract:
Composite tumors of the adrenal medulla are rare and have been reported in both the presence and the absence of phacomatosis. Composite pheochromocytoma of the adrenal gland in multiple endocrine neoplasia 2B has not been reported so far. We report a case of a 27-year-old woman with marfanoid habitus and numerous mucosal neuromas of the oral cavity and the eyelids. Clinical investigations revealed a left adrenal medullary tumor and bilateral thyroid nodules. Histologic examination confirmed the presence of typical pheochromocytoma with large areas of ganglioneuroma and multifocal medullary carcinoma with cervical lymph nodes metastases. Our report is the first to describe composite pheochromocytoma with multiple endocrine neoplasia 2B; this report underlines the diversity of neoplasms that could be encountered in this disease and the complex mechanisms involved in its pathogenesis.
Related Concept Videos
Cushing Syndrome II: Pathophysiology
Cushing Syndrome I: Introduction
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Type II Diabetes II: Pathophysiology
Hyperthyroidism II: Pathophysiology
Type II Diabetes I: Introduction