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Studying Cryptosporidium Infection in 3D Tissue-derived Human Organoid Culture Systems by Microinjection
Published on: September 14, 2019
Using infectious intestinal disease surveillance data to explore illness aetiology; a cryptosporidiosis case study
Iain R Lake1, Gordon Nichols, Florence C D Harrison
1School of Environmental Sciences, University of East Anglia, Norwich NR4 7TJ, UK. i.lake@uea.ac.uk
Abstract:
Infectious intestinal disease (IID) surveillance data are an under-utilised information source on illness geography. This paper uses a case study of cryptosporidiosis in England and Wales to demonstrate how these data can be converted into area-based rates and the factors underlying illness geography investigated. Ascertainment bias is common in surveillance datasets, and we develop techniques to investigate and control this. Rural areas, locations with many livestock and localities with poor water treatment had elevated levels of cryptosporidiosis. These findings accord with previous research validating the techniques developed. Their use in future studies investigating IID geography is therefore recommended.
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