Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Restraint of melanoma progression by cells in the local skin environment.

eLife·2026
Same author

Compositional and interpretable representation of histology using AI foundation models and sparse autoencoders.

bioRxiv : the preprint server for biology·2026
Same author

Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis.

bioRxiv : the preprint server for biology·2026
Same author

Induced chromosomal instability in triple negative breast cancer cells promotes M2-like polarization of macrophages.

Scientific reports·2026
Same author

Volumetric Cyclic Immunofluorescence for 3D Spatial Profiling of Immune Structures in Human FFPE Tissue.

bioRxiv : the preprint server for biology·2026
Same author

Author Correction: Biophysical prediction of protein-peptide interactions and signaling networks using machine learning.

Nature methods·2026

Related Experiment Video

Updated: Jul 2, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

Studying chromosome instability in the mouse.

Floris Foijer1, Viji M Draviam, Peter K Sorger

  • 1Harvard Medical School, Department of Systems Biology, 200 Longwood Avenue, Boston, MA 02115, USA.

Biochimica Et Biophysica Acta
|August 19, 2008
PubMed
Summary

Aneuploidy, or abnormal chromosome numbers, is a cancer hallmark. Disrupting spindle checkpoint genes in mice reveals its role in tumor development and premature aging, clarifying its oncogenic significance.

More Related Videos

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes
10:09

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Published on: September 13, 2022

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II
10:39

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II

Published on: February 26, 2018

Related Experiment Videos

Last Updated: Jul 2, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
07:54

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH

Published on: August 19, 2014

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes
10:09

Evaluation of the Spindle Assembly Checkpoint Integrity in Mouse Oocytes

Published on: September 13, 2022

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II
10:39

Chromatin Spread Preparations for the Analysis of Mouse Oocyte Progression from Prophase to Metaphase II

Published on: February 26, 2018

Area of Science:

  • Genetics
  • Cell Biology
  • Oncology

Background:

  • Aneuploidy is a recognized hallmark of cancer, but its causal role in tumorigenesis remains debated.
  • It is unclear if aneuploidy initiates cancer or results from late-stage cell cycle dysregulation.
  • The spindle assembly checkpoint (SAC) ensures accurate chromosome segregation during mitosis.

Purpose of the Study:

  • To investigate the role of aneuploidy in cancer initiation and progression.
  • To understand the consequences of disrupting spindle checkpoint genes in vivo.
  • To explore potential links between aneuploidy, tumorigenesis, and aging.

Main Methods:

  • Germ-line knockout mouse models were generated by disrupting spindle checkpoint genes.
  • The study analyzed the effects of these mutations on embryonic development and tumor progression.
  • Phenotypic consequences, including aging, were assessed in mutant mice.

Main Results:

  • Disruption of spindle checkpoint genes led to aneuploidy and altered tumor progression.
  • Specific mutations impacted embryonic development, indicating critical roles for these genes.
  • An unexpected association between aneuploidy and premature aging was observed.

Conclusions:

  • Aneuploidy resulting from spindle checkpoint dysfunction contributes to cancer development.
  • Spindle checkpoint gene mutations have pleiotropic effects, influencing development, cancer, and aging.
  • Further research is warranted to fully elucidate the complex interplay between aneuploidy and disease.