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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
A controlled-release ocular delivery system for ibuprofen based on nanostructured lipid carriers
Xiang Li1, Shu-fang Nie, Jun Kong
1Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, PR China. lixiangdoudou@163.com
International Journal of Pharmaceutics
|August 19, 2008
Summary
This study developed novel ibuprofen nanostructured lipid carriers for enhanced ocular delivery. The optimized formulation significantly improved corneal permeability and prolonged drug retention, offering a promising alternative to conventional eye drops.
Area of Science:
- Ophthalmology
- Pharmaceutics
- Nanotechnology
Background:
- Developing effective ocular drug delivery systems is crucial for treating eye diseases.
- Conventional eye drops often suffer from poor bioavailability and short precorneal residence time.
- Nanostructured lipid carriers (NLCs) offer potential for improved drug delivery due to their unique properties.
Purpose of the Study:
- To develop and characterize ocular nanostructured lipid carriers (NLCs) for ibuprofen delivery.
- To investigate the in vitro and in vivo performance of ibuprofen-loaded NLCs.
- To evaluate the impact of NLC components on corneal permeability and drug release.
Main Methods:
- Four formulations of ibuprofen NLCs were prepared using the melted-ultrasonic method.
- Gelucire 44/14 was identified as a suitable lipid matrix material.
- In vitro corneal permeability was assessed using modified Franz-type diffusion cells.
- In vivo drug release was evaluated using the microdialysis technique.
Main Results:
- Gelucire 44/14 and Transcutol P enhanced ibuprofen corneal permeability (1.28x and 1.36x, respectively).
- Stearylamine demonstrated a potential to prolong precorneal drug retention.
- The optimized ibuprofen NLC formulation exhibited controlled-release properties.
- The AUC of the optimized NLCs was 3.99 times higher than conventional ibuprofen eye drops.
Conclusions:
- Ibuprofen-loaded NLCs represent a promising ocular drug delivery system.
- The developed NLCs significantly improve ibuprofen's corneal permeability and ocular bioavailability.
- This nanocarrier system offers a potential for sustained drug release and prolonged therapeutic effect.
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