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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...

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Related Experiment Video

Updated: Jul 2, 2026

Study of Experimental Organ Donation Models for Lung Transplantation
08:56

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

Current strategies in donor selection and management.

Phil Botha1, Anthony J Rostron, Andrew J Fisher

  • 1Department of Cardiopulmonary Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom.

Seminars in Thoracic and Cardiovascular Surgery
|August 19, 2008
PubMed
Summary

Lung donor selection and management strategies are evolving due to donor lung scarcity and graft dysfunction risks. Objective data improves donor lung selection, but some factors like ventilation duration and ischemic time need further research.

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Related Experiment Videos

Last Updated: Jul 2, 2026

Study of Experimental Organ Donation Models for Lung Transplantation
08:56

Study of Experimental Organ Donation Models for Lung Transplantation

Published on: March 15, 2024

Pre-clinical Model of Cardiac Donation after Circulatory Death
06:26

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Published on: August 2, 2019

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death
09:54

Lung Rapid Recovery Procurement Combined with Abdominal Normothermic Regional Perfusion in Controlled Donation after Circulatory Death

Published on: August 15, 2022

Area of Science:

  • Thoracic Surgery
  • Transplantation Medicine
  • Critical Care Medicine

Background:

  • Lung transplantation faces challenges due to donor lung scarcity and primary graft dysfunction.
  • Traditional donor lung selection relied heavily on transplant surgeon experience.
  • Evolving strategies aim to improve donor lung utilization and transplant outcomes.

Purpose of the Study:

  • To review current strategies for lung donor selection and management.
  • To highlight the increasing objectivity in donor lung decision-making.
  • To identify areas requiring further investigation in lung donor management.

Main Methods:

  • Analysis of clinical data influencing donor lung selection (e.g., age, gas exchange, gram-stain, cytokine expression).
  • Discussion of the pathophysiology of brain-stem death in relation to donor management.
  • Review of factors with unclear significance, such as ventilation duration and ischemic time.

Main Results:

  • Objective clinical data enhances the decision-making process for lung donor selection.
  • Understanding brain-stem death pathophysiology informs optimal donor lung management.
  • The impact of ventilation duration and ischemic time on donor lung quality remains uncertain.

Conclusions:

  • Lung donor selection is becoming more data-driven, moving beyond subjective experience.
  • Optimal management strategies are emerging based on a better understanding of brain-stem death.
  • Further research is needed to clarify the role of specific variables and validate proposed management algorithms.