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A Protocol for Rapid Post-mortem Cell Culture of Diffuse Intrinsic Pontine Glioma (DIPG)
Published on: March 7, 2017
Primary diffuse leptomeningeal gliomatosis.
A Singh1, C Kesavadas, M Radhakrishnan
1Department of Neurology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, India.
Journal of Neuroradiology = Journal De Neuroradiologie
|August 19, 2008
Summary
A rare case of primary diffuse leptomeningeal gliomatosis in a young woman presented with neurological deficits. The patient achieved long-term survival without aggressive treatment, highlighting a unique clinical course.
Area of Science:
- Neuro-oncology
- Neurology
- Pathology
Background:
- Primary diffuse leptomeningeal gliomatosis is a rare condition characterized by widespread leptomeningeal infiltration by glial tumor cells.
- This case presents a diagnostic and therapeutic challenge due to its rarity and diffuse nature.
Observation:
- A 20-year-old woman with a history of seizures developed progressive walking difficulties.
- Clinical findings suggested a craniovertebral junction anomaly.
- Cerebrospinal fluid analysis revealed mild protein elevation without signs of infection.
Findings:
- Craniospinal MRI demonstrated diffuse nodular leptomeningeal enhancement throughout the brain and spinal cord.
- Histopathology confirmed a low-grade glioma, leading to the diagnosis of primary diffuse leptomeningeal gliomatosis.
- The patient exhibited an unexpectedly prolonged survival of over 110 months without requiring aggressive therapy.
Implications:
- This case underscores the importance of considering rare diagnoses in patients with complex neurological symptoms.
- The patient's long-term survival without aggressive treatment suggests potential for favorable outcomes in select cases of primary diffuse leptomeningeal gliomatosis.
- Further research into the biological behavior and treatment strategies for this rare condition is warranted.
