High resolution T2 weighted liver MR imaging using functional residual capacity breath-hold with a 1.0-Tesla scanner

During acquisition of rapid high resolution (HR) T2 weighted (T2W) liver magnetic resonance (MR) images using a 1.0-Tesla (T) scanner, the liver is segmented into odd and even sections that are acquired at two different times using the multi-breath-hold (MBH) strategy. Misalignment between the two breath-hold (B-H) images may result in the occurrence of a blind area and a decrease in diagnostic accuracy. Here, a functional residual capacity (FRC) B-H method was developed to overcome this problem.

Twenty-five volunteers were enrolled. The sagittal images were reconstructed from whole liver transverse images. When the B-H phases are different, misalignment may occur in the craniocaudal and anterior-posterior (AP) directions. In this study, misalignments of the abdominal wall were measured in the AP direction. The misalignment was compared between four B-H phases, maximum inspiration (MI), maximum expiration (ME), voluntary expiration (VE) and FRC using one-way repeated measures ANOVA. Differences between groups were compared using the t-test for multi-group comparisons. In addition, qualitative analysis of misalignment was performed between VE and FRC in 52 clinical patients and the chi(2) test was performed.

The misalignment widths of FRC, ME, MI and VE B-Hs were 2.7+/-3.8, 6.4+/-7.4, 9.1+/-8.4 and 6.0+/-6.7 mm, respectively. Misalignment of the liver position using FRC was significantly smaller than for the other B-H methods (p<0.05). Significant differences between the VE B-H and FRC B-H were also observed in the qualitative analysis (p<0.05).

The liver positions obtained when using FRC B-H were significantly more reproducible than when using the other B-H methods. The FRC B-H method resulted in a reduction in the blind area and an extension of the diagnostic area to the whole liver.