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Factor XII deficiency and pregnancy.

T T Lao¹, R M Lewinsky, A Ohlsson

¹Regional Perinatal Unit, Women's College Hospital, Toronto, Ontario, Canada.

Obstetrics and Gynecology

|September 1, 1991

Summary

Pregnancy with factor XII deficiency can be uncomplicated, even with preterm labor and placental abruption. Pregnant individuals with prolonged aPTT should be screened for factor deficiencies to prevent thromboembolism.

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Area of Science:

Obstetrics and Gynecology
Hematology

Background:

Factor XII deficiency is a rare bleeding disorder.
Pregnancy in women with factor XII deficiency has limited documented cases.
Thromboembolic risks are known in nonpregnant individuals with factor XII deficiency.

Observation:

A 19-year-old primigravida with known factor XII deficiency presented with placental abruption and preterm labor at 26 weeks' gestation.
A healthy infant was delivered vaginally with no complications for mother or infant.
The infant had normal factor XII levels for her age.

Findings:

Factor XII deficiency did not lead to postpartum hemorrhage or neonatal hemorrhage in this case.
Pregnancy outcomes can be favorable despite factor XII deficiency and obstetric complications.

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Limited previous reports also indicate uncomplicated pregnancies with factor XII deficiency.

Implications:

Pregnant women with prolonged activated partial thromboplastin time (aPTT) should be investigated for factor deficiencies (VIII, IX, XII).
Screening is crucial for identifying potential bleeding or thromboembolic risks during pregnancy.
Appropriate counseling and monitoring for thromboembolism are recommended for confirmed factor XII deficiency cases.