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High-resolution Spatiotemporal Analysis of Receptor Dynamics by Single-molecule Fluorescence Microscopy
Published on: July 25, 2014
A simple reaction kinetic model of rapid (G protein dependent) and slow (beta-Arrestin dependent) transmission
Dávid Csercsik1, Katalin M Hangos, György M Nagy
1Process Control Research Group, Systems and Control Laboratory, Computer and Automation Research Institute, Hungarian Academy of Sciences, P.O. Box 63, H-1518 Budapest, Hungary. csercsik@scl.sztaki.hu
Abstract:
In this paper the qualitative dynamic behavior of reaction kinetic models of G protein signaling is examined. A simplified basic G protein signaling structure is defined, which is extended to be able to take the effect of slow transmission, RGS mediated feedback regulation and ERK-phosphatase mediated feedback regulation into account. The resulting model gives rise to an acceptable qualitative approximation of the G protein dependent and independent ERK activation dynamics that is in good agreement with the experimentally observed behavior.
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