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Published on: January 22, 2015
Characterization of folate-graft-chitosan as a scaffold for nitric oxide release
1School of Chemistry & Chemical Technology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China. wanajun@sjtu.edu.cn
Abstract:
The preparation and characterization of nitric oxide (NO)-releasing chitosan-folate conjugates were reported. The secondary amine chitosan-folate conjugates exhibited a high storage capacity for NO (up to 84.3 nmol NO/mg) (when the graft rate of folate was 12.5%), greatly increasing the "payload" of released NO with the graft rate of folate increasing. The NO release durations (12h) observed for secondary amine the chitosan-folate conjugates with the high graft rate (12.5%) were largerly shorter compared to O2-protected diazeniumliolates with BrCH2CH3 (24 h), thus illustrating a macromolecular effect on NO release kinetics.
