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Related Experiment Video

Updated: Jul 2, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

Chicken breast attenuates high-intensity-exercise-induced decrease in rat sarcoplasmic reticulum Ca2+ handling.

Takaaki Mishima1, Takashi Yamada, Makoto Sakamoto

  • 1Preschool Education Department, Hachinohe Junior College, Hachinohe, Japan.

International Journal of Sport Nutrition and Exercise Metabolism
|August 19, 2008
PubMed
Summary

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Dietary chicken-breast extract (CBEX) increases muscle carnosine and anserine. CBEX supplementation may protect sarcoplasmic reticulum function from high-intensity exercise-induced impairments.

Area of Science:

  • Exercise Physiology
  • Muscle Biochemistry

Background:

  • Sarcoplasmic reticulum (SR) function is crucial for muscle contraction and relaxation.
  • High-intensity exercise can impair SR Ca2+-handling ability, affecting muscle performance.
  • Histidine-containing dipeptides, found in chicken-breast extract (CBEX), are known for their antioxidant properties.

Purpose of the Study:

  • To investigate the effects of dietary chicken-breast extract (CBEX) on exercise-induced changes in sarcoplasmic reticulum (SR) function.
  • To determine if CBEX supplementation can mitigate exercise-induced impairments in SR Ca2+-handling.

Main Methods:

  • Rats were fed a diet supplemented with CBEX for 5 weeks.
  • SR Ca2+-handling ability was assessed in vastus lateralis muscles after high-intensity running (2.5 min).

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Last Updated: Jul 2, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
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Published on: September 18, 2017

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  • Muscle carnosine and anserine concentrations, SR Ca2+-ATPase activity, and Ca2+ uptake/release rates were measured.

    • Main Results:

    • Dietary CBEX significantly increased muscle carnosine (approx. 15%) and anserine (approx. 45%) concentrations.
    • High-intensity exercise depressed SR Ca2+-handling ability in both groups.
    • CBEX-fed rats exhibited a lesser degree of SR Ca2+ handling reduction compared to control rats.

    Conclusions:

    • Dietary CBEX supplementation increases muscle histidine-containing dipeptide concentrations.
    • CBEX may attenuate exercise-induced deteriorations in sarcoplasmic reticulum Ca2+-handling ability.
    • This suggests a potential ergogenic effect of CBEX for high-intensity exercise performance.