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Related Concept Videos

Multi-species Conserved Sequences02:51

Multi-species Conserved Sequences

Next-generation sequencing technologies have created large genomic databases of a variety of animals and plants. Ever since the human genome project was completed, scientists studied the genome of primates, mammals, and other phylogenetically distant living beings. Such large-scale  studies have provided new insights into the evolutionary relationship between organisms.
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Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
Conserved Binding Sites01:49

Conserved Binding Sites

Many proteins’ biological role depends on their interactions with their ligands, small molecules that bind to specific locations on the protein known as ligand-binding sites. Ligand-binding sites are often conserved among homologous proteins as these sites are critical for protein function.
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Genomics02:02

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Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
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Published on: August 21, 2016

Ultraconserved elements: genomics, function and disease.

Eirini Baira1, Joel Greshock, George Coukos

  • 1Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

RNA Biology
|August 19, 2008
PubMed
Summary
This summary is machine-generated.

Ultraconserved elements (UCEs), highly conserved genomic sequences across species, play crucial roles in gene regulation. Altered UCE expression in tumors suggests their involvement in cancer development.

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Last Updated: Jul 2, 2026

Screening for Functional Non-coding Genetic Variants Using Electrophoretic Mobility Shift Assay (EMSA) and DNA-affinity Precipitation Assay (DAPA)
11:35

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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
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Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease

Published on: April 4, 2018

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Evolutionary conservation is key to identifying functional genomic elements.
  • Ultraconserved elements (UCEs) are genomic segments (>200 bp) with 100% identity across human, mouse, and rat genomes.
  • Limited knowledge exists on UCEs, but emerging evidence points to significant roles.

Purpose of the Study:

  • To highlight the functional significance of ultraconserved elements in vertebrate genomes.
  • To explore the potential involvement of UCEs in human diseases, particularly cancer.

Main Methods:

  • Comparative genomics to identify conserved sequences.
  • Analysis of UCE function, including gene regulation and epigenetic modifications.
  • Examination of UCE expression patterns in tumor samples.

Main Results:

  • Identified 481 ultraconserved elements longer than 200 bp between human, mouse, and rat.
  • UCEs are implicated in regulating flanking genes, splicing, epigenetic modifications, and transcriptional activation.
  • UCE expression is consistently altered in tumors.

Conclusions:

  • Ultraconserved elements are functionally important in vertebrate genomes.
  • Altered UCE expression in tumors suggests a role in cancer development.
  • Further research into UCEs could reveal new insights into disease mechanisms.