Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Middle ear inflammatory mediators and cochlear function.

T Morizono1, T Tono

  • 1Department of Otolaryngology, University of Minnesota Medical School, Minneapolis.

Otolaryngologic Clinics of North America
|August 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of tinnitus severity and associated risk factors in patients with chronic otitis media: data from the multinational collaborative Chronic Otitis Media Questionnaire-12 study.

The Journal of laryngology and otology·2022
Same author

Three-dimensional reversed fast imaging with steady-state precession diffusion-weighted imaging for the detection of middle ear cholesteatoma.

Clinical radiology·2019
Same author

Purification and Characterization of Arctium lappa L. (Edible Burdock) Polyphenol Oxidase.

Bioscience, biotechnology, and biochemistry·2016
Same author

Production of a human antibody fragment against the insulin-like growth factor І receptor as a fusion protein.

Drug discoveries & therapeutics·2012
Same author

Mutations in the NOG gene are commonly found in congenital stapes ankylosis with symphalangism, but not in otosclerosis.

Clinical genetics·2012
Same author

Ototoxicity of Povidone-Iodine applied to the middle ear cavity of guinea pigs.

International journal of pediatric otorhinolaryngology·2011
Same journal

Little Tube; Big Problems: Eustachian Tube Dysfunction.

Otolaryngologic clinics of North America·2026
Same journal

Current State of Button Battery Ingestion Injuries.

Otolaryngologic clinics of North America·2026
Same journal

Diagnostic Algorithm for Eustachian Tube Dysfunction and Indications for Balloon Dilation of the Eustachian Tube.

Otolaryngologic clinics of North America·2026
Same journal

Patulous Eustachian Tube Dysfunction.

Otolaryngologic clinics of North America·2026
Same journal

Revisiting Eustachian Tube Anatomy and Physiology.

Otolaryngologic clinics of North America·2026
Same journal

Glottic Stenosis.

Otolaryngologic clinics of North America·2026
See all related articles

Middle ear inflammation, like otitis media, can cause sensorineural hearing loss (SNHL). Animal studies show inflammatory mediators entering the inner ear via the round window membrane contribute to cochlear dysfunction and hearing impairment.

Area of Science:

  • Otolaryngology
  • Neuroscience
  • Immunology

Background:

  • Sensorineural hearing loss (SNHL) is a known complication of otitis media.
  • Existing research primarily focuses on clinical and pathological aspects, with limited animal studies investigating the link between middle ear inflammation and cochlear function.

Purpose of the Study:

  • To explore the relationship between middle ear inflammation and sensorineural hearing loss using animal models.
  • To investigate the role of inflammatory mediators and the round window membrane in cochlear dysfunction.

Main Methods:

  • Inducing middle ear inflammation in rodents and chinchillas through bacterial inoculation, ototoxins, inflammatory products, or human serum albumin.
  • Assessing the resulting sensorineural hearing loss and cochlear function alterations.

Related Experiment Videos

  • Examining the role of the round window membrane's permeability to inflammatory mediators.

    • Main Results:

    • Experimental middle ear inflammation in animal models successfully induced sensorineural hearing loss.
    • Inflammatory mediators were found to enter the inner ear primarily through the round window route.
    • Alterations in the round window membrane's permeability were implicated in cochlear dysfunction.

    Conclusions:

    • Middle ear inflammation is a significant cause of sensorineural hearing loss.
    • The round window membrane plays a critical role in mediating cochlear damage from middle ear inflammation.
    • Further research is needed to understand the immunologic responses within the inner ear related to middle ear inflammatory mediators.