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Updated: Jul 2, 2026
In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
Published on: February 16, 2016
Value of myocardial regional perfusion on long-term function in collateral-dependent myocardium
Jun Jin1, Lan Huang, Hong Wang
1Division of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing City, People's Republic of China. jj.xqyy@yahoo.com.cn
Insights
Myocardial regional perfusion, assessed by echocardiography, significantly impacts left ventricular function recovery in chronic total occlusion patients post-revascularization. Myocardial contrast echocardiography aids in prognosis and risk stratification.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Diagnostic Imaging
Background:
- Collateral circulation is vital for left ventricular (LV) function recovery in chronic total occlusion (CTO) patients.
- The precise role of collaterals in LV recovery post-revascularization remains debated.
Purpose of the Study:
- To investigate the influence of myocardial regional perfusion on LV function recovery in CTO patients.
- To evaluate the prognostic value of myocardial contrast echocardiography (MCE) in this patient group.
Main Methods:
- Echocardiography was used to assess regional myocardial perfusion, wall motion score (WMS), and left ventricular ejection fraction (LVEF).
- Patients with angiographically visible collateral circulation (grades 2 and 3) were included.
- Myocardial contrast echocardiography (MCE) was utilized for scoring.
Main Results:
- Significant improvements in WMS and LVEF were observed at 1 and 6 months in patients with myocardial regional perfusion (Group B) compared to those without (Group A).
- A significant correlation was found between myocardial regional blood flow and changes in WMS and LVEF at 6 months.
- Similar correlations were noted with the MCE score index.
Conclusions:
- Myocardial function recovery in CTO patients is primarily determined by myocardial regional perfusion.
- MCE is a valuable tool for prognosis and risk stratification in CTO patients undergoing cardiac catheterization.
Background:
Collateral circulation is considered key for left ventricular (LV) function recovery in patients with chronic total occlusion (CTO). However, there are conflicting reports about the influence of collaterals on LV recovery after revascularization.
Methods:
Echocardiographic assessment of regional myocardial perfusion, wall motion score (WMS), and left ventricular ejection fraction (LVEF) were performed in patients with angiographically visible collateral circulation of grades 2 and 3.
Results:
The WMS and LVEF of group B (with presence of myocardial regional perfusion) were significantly improved at one month and six months compared to those of group A (with absence of myocardial regional perfusion). The correlation between myocardial regional blood flow and changes in WMS and LVEF was significant at 6 months in patients with angiographically visible collateral circulation of grade 2 and 3. Similar correlations were observed on myocardial contrast echocardiography (MCE) score index.
Conclusion:
Myocardial function recovery in patients with CTO is determined by myocardial regional perfusion. MCE has important value for prognosis and risk stratification in patients with CTO undergoing cardiac catheterization.
