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Cell Adhesion Molecules - Types and Functions

Cell Adhesion Molecules - Types and Functions

Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Related Experiment Video

Updated: Jul 2, 2026

Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

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Published on: December 5, 2025

Adiponectin: good, bad, or just plain ugly?

Tina Costacou¹, Trevor J Orchard

¹Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. costacout@edc.pitt.edu

Kidney International

|August 19, 2008

Summary

Adiponectin, a hormone with anti-inflammatory and insulin-sensitizing effects, shows conflicting associations with disease states in human studies. This commentary explores these discrepancies in the scientific literature.

Area of Science:

Endocrinology
Metabolic Syndrome
Cardiovascular Research

Background:

Adiponectin is recognized for its potential antiatherogenic, anti-inflammatory, and insulin-sensitizing properties.
Existing research suggests a complex role for adiponectin in various disease states.

Discussion:

Human studies present conflicting findings, reporting both inverse and positive associations between adiponectin levels and disease.
This apparent paradox necessitates a deeper examination of the factors influencing adiponectin's relationship with health and disease.

Key Insights:

The relationship between adiponectin concentrations and disease states is not consistently linear.
Discrepancies in study outcomes may stem from differences in methodology, patient populations, or specific disease contexts.

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Published on: July 17, 2018

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Characterization of Adipocyte-Derived Extracellular Vesicle Secretion Using a CD63-GFP Reporter Mouse Model In Vivo and In Vitro

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Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue

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Published on: July 17, 2018

Outlook:

Further research is needed to reconcile the conflicting data on adiponectin and disease.
Clarifying adiponectin's role is crucial for understanding metabolic and cardiovascular health and developing targeted therapies.