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Related Experiment Video

Updated: Jul 2, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

Microfluidic chip-based valveless flow injection analysis system with gravity-driven flows.

Yang-Zhen Huang1, Wen-Bin Du, Jian-Zhang Pan

  • 1Institute of Microanalytical Systems, Chemistry Department, Zhejiang University (Zijingang Campus), Hangzhou 310058, China.

The Analyst
|August 19, 2008
PubMed
Summary
This summary is machine-generated.

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This study presents a novel microfluidic chip for valveless flow injection analysis (FIA) using gravity-driven flow and liquid-core waveguide (LCW) detection. The system enables automated, micro-volume sample injection without microvalves, demonstrating high accuracy for nitrite determination.

Area of Science:

  • Analytical Chemistry
  • Microfluidics
  • Spectrometry

Background:

  • Microfluidic systems offer miniaturization and reduced reagent consumption.
  • Traditional flow injection analysis (FIA) often relies on complex microvalves.
  • Developing integrated, valve-less analytical systems is crucial for portable diagnostics.

Purpose of the Study:

  • To develop a microfluidic chip-based valveless FIA system.
  • To integrate liquid-core waveguide (LCW) spectrometric detection on-chip.
  • To demonstrate automated, micro-volume sample injection and analysis.

Main Methods:

  • Utilized gravity-driven flow on a microfluidic chip.
  • Implemented a novel gated injection mode by controlling waste reservoir position.

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Last Updated: Jul 2, 2026

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
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Published on: October 1, 2007

A Microfluidic-based Hydrodynamic Trap for Single Particles
10:13

A Microfluidic-based Hydrodynamic Trap for Single Particles

Published on: January 21, 2011

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  • Integrated a Teflon AF 2400 capillary as a liquid-core waveguide (LCW) flow cell.
  • Employed a green LED light source and photodiode detector.
  • Applied the Saltzman reaction for nitrite determination.

    • Main Results:

    • Achieved automated sample injection in the 0.3-6.4 nL range without microvalves.
    • Demonstrated linear absorbance response for nitrite determination from 0.1-20 mg L(-1) (R(2) = 0.9910).
    • Obtained excellent reproducibility with 0.34% relative standard deviation (RSD).

    Conclusions:

    • Developed a functional microfluidic chip-based valveless FIA system.
    • The integrated LCW spectrometric detection provides sensitive and reproducible analysis.
    • This valve-less, gravity-driven system is a promising platform for portable analytical devices.