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Updated: Jul 2, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Inflammation and hypercoagulable state in adult psoriatic men

Ozlem Karabudak1, Rifat Eralp Ulusoy, Alev Akyol Erikci

  • 1Department of Dermatology, GATA Teaching Hospital, GATA Teaching Hospital, Istanbul, Turkey. okarabudak@yahoo.com

Acta Dermato-Venereologica
|August 19, 2008
PubMed

Insights

Psoriasis patients show elevated inflammation markers and altered homocysteine levels, suggesting a link between these factors and increased cardiovascular risk in the skin condition.

Area of Science:

  • Dermatology
  • Cardiology
  • Hematology

Background:

  • Hyperhomocysteinaemia is a known risk factor for cardiovascular disease and atherothrombosis.
  • Psoriasis, an inflammatory skin disease, is associated with increased thrombotic events.

Purpose of the Study:

  • To investigate serum homocysteine levels in psoriasis patients.
  • To explore the relationship between homocysteine, inflammatory markers, and atherothrombotic factors in psoriasis.

Main Methods:

  • Study included 20 patients with mild/moderate psoriasis and 20 healthy controls.
  • Exclusion criteria: acquired hyperhomocysteinaemia.
  • Measured serum homocysteine, inflammation markers (CRP, ceruloplasmin), mean platelet volume, antithrombin III, folic acid, and coagulation factors.

Main Results:

  • Psoriasis group had significantly higher inflammation markers (mean platelet volume, CRP, ceruloplasmin) than controls.
  • Psoriasis group showed decreased antithrombin III and total homocysteine levels.
  • Folic acid levels correlated inversely with homocysteine and positively with fibrinogen.

Conclusions:

  • Elevated homocysteine and inflammation markers may contribute to the atherothrombotic state in psoriasis.
  • Findings suggest a potential link between psoriasis, homocysteine metabolism, and cardiovascular risk.

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