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Updated: Jul 2, 2026
Determining Bile Duct Density in the Mouse Liver
Published on: April 30, 2019
Liver/spleen volume ratio as a predictor of prognosis in primary biliary cirrhosis
Yosuke Murata1, Masanori Abe, Yoichi Hiasa
1Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, 791-0295, Japan.
Background:
The course of primary biliary cirrhosis (PBC) is determined by clinical symptoms and histological findings. The present study examined the prognostic importance of imaging parameters in PBC.
Methods:
The volumes of the liver and spleen of patients with PBC were assessed by computed tomography (CT). The volume ratio of liver to spleen (LV/SV ratio) was evaluated and used for further analyses.
Results:
The prognosis was significantly poorer in PBC patients with a low, rather than high, LV/SV ratio. The Cox proportional hazard regression model showed that the serum bilirubin level and the LV/SV ratio could predict the prognosis of PBC patients. In addition, the LV/SV ratio was significantly lower in patients who developed symptoms (s-PBC) than in those who remained asymptomatic (a-PBC) during the observation period.
Conclusions:
The LV/SV ratio is of prognostic importance in patients with PBC.
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