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Related Concept Videos

Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Diabetic Neuropathy01:22

Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...
Blood and Nerve Supply to the Kidney01:18

Blood and Nerve Supply to the Kidney

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Bloody Supply to the Kidneys:
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Glial Cells01:04

Glial Cells

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Related Experiment Video

Updated: Jul 2, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

Peripheral nerves and nerve function in highland Ethiopians.

M Elizabeth Duncan1, Stig Hansen, Terefe Tadesse

  • 1Armauer Hansen Research Institute, Addis Ababa, Ethiopia.

Ethiopian Medical Journal
|August 20, 2008
PubMed
Summary

This study established normal nerve function test values for Highland Ethiopians, crucial for diagnosing peripheral nerve issues like those caused by leprosy. Findings detail factors influencing nerve function and size in this population.

Related Experiment Videos

Last Updated: Jul 2, 2026

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
08:19

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry

Published on: May 5, 2022

Area of Science:

  • Neurology
  • Tropical Medicine
  • Ethiopian Public Health

Background:

  • Leprosy commonly causes peripheral nerve dysfunction in Ethiopia.
  • Standard nerve function tests (NFT) lack established normal values for Highland Ethiopians.
  • Physiological nerve enlargement is recognized but poorly documented.

Purpose of the Study:

  • Determine normal nerve function test values in Highland Ethiopians.
  • Establish baseline data for peripheral nerve function assessment.
  • Document factors influencing nerve function and size.

Main Methods:

  • Assessed 236 healthy students and adults (aged 10-75) in a low-endemic leprosy area.
  • Utilized Voluntary Muscle Test (VMT), Graded Sensory Skin Test (STG), 2-Point Discrimination, and Thermal Threshold Test.
  • Excluded two individuals with leprosy from analysis.

Main Results:

  • NFT thresholds varied with age, exercise, skin factors, domicile, and organophosphate exposure.
  • Nerve size was influenced by age, gender, exercise, skin fold thickness, and BMI.
  • Exercise-related physiological nerve enlargement was documented.

Conclusions:

  • Provides essential baseline data for peripheral nerve function in Highland Ethiopians.
  • Supports improved diagnosis and management of nerve conditions in the region.
  • Highlights the impact of various factors on nerve health.