Related Experiment Video
Updated: Jul 2, 2026

10:12
Construction of Cyclic Cell-Penetrating Peptides for Enhanced Penetration of Biological Barriers
Published on: September 19, 2022
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications
John J Hall1, Madhavi Sriram, Tracy E Strecker
1Department of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798-7348, USA.
Bioorganic & Medicinal Chemistry Letters
|August 20, 2008
Abstract:
A new trifluorinated amino-combretastatin analogue, (Z)-2-(4'-methoxy-3'-aminophenyl)-1-(3,4,5-trifluorophenyl)ethene, prepared by chemical synthesis, was found to be a potent inhibitor of tubulin assembly (IC(50)=2.9 microM), and cytotoxic against selected human cancer cell lines. This new lead compound is among the most active from a group of related structural modifications.

