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Laser-induced Breakdown Spectroscopy: A New Approach for Nanoparticle's Mapping and Quantification in Organ Tissue
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Published on: June 18, 2014

Elemental analysis using micro laser-induced breakdown spectroscopy (microLIBS) in a microfluidic platform.

Yogesh Godwal1, Govind Kaigala, Viet Hoang

  • 1Department of Electrical and Computer Engineering, University of Alberta, Edmonton, AB, Canada.

Optics Express
|August 20, 2008
PubMed
Summary

We developed a novel, non-labeled elemental analysis method for microfluidic chips, enabling sensitive sodium detection. This technique integrates laser-induced breakdown spectroscopy (LIBS) with microfluidics for portable elemental analysis.

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Area of Science:

  • Analytical Chemistry
  • Microfluidics
  • Spectroscopy

Background:

  • Elemental analysis of small fluid volumes is crucial for understanding composition.
  • Existing methods often require labeling or complex instrumentation.
  • Microfluidic platforms offer miniaturization potential for portable analysis.

Purpose of the Study:

  • To present a non-labeled elemental analysis detection technique for microfluidic chips.
  • To demonstrate the sensitive detection of sodium (Na) using this method.
  • To explore the feasibility of a portable, low-power elemental analysis system.

Main Methods:

  • Development of a microfluidic chip with a patterned thin film resistive element.
  • Utilizing the resistive element to generate micro-bubbles for micro-droplet extrusion.
  • Integration of laser-induced breakdown spectroscopy (LIBS) for elemental detection.
  • Employing a non-valved microchip compatible with continuous flow systems.

Main Results:

  • Successful demonstration of a non-labeled elemental analysis technique on a microfluidic chip.
  • Sensitive detection of sodium (Na) in micro-droplets.
  • Proof-of-concept for a portable, low-power LIBS system integrated with microfluidics.

Conclusions:

  • The presented technique offers a simple, non-labeled approach for elemental analysis in microfluidic systems.
  • This integration of LIBS and microfluidics is a significant step towards portable elemental analysis.
  • The method shows broad applicability for analyzing fluid composition in various fields.